Botanical Nutrition

by Rob Seeman official blogger of the health food movement


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Super Hemp CBD video

New product review on Super Hemp CBD

Explains quickly and easily why you should be interested in this exciting ‘new’ dietary supplement from the Food Movement. This pioneering extract of CBD (cannabidiol) from industrial hemp is a safe and legal product offering new options for consumers.hempmovement

Because dietary supplements are regulated by the FDA, no one selling Hemp CBD can make health claims.  But an ever-growing body of research suggests that they may just be of immense benefit.  The video explainer above gives you some insights into the product and also a $10 coupon code SAVEONSUPERHEMP for your first order!

Join the Hemp Movement today!


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AHPA responds to NY Attorney General’s big box supplements slam

Walmart

On Monday, the NY Times reported that the New York Attorney General’s office had accused four major retailers (Walgreen’s Wal-Mart, Target and GNC) of having adulterated and useless (or potentially harmful) products on their shelves.  The paper of record reported that “The authorities said they had conducted tests on top-selling store brands of herbal supplements at four national retailers — GNC, Target, Walgreens and Walmart — and found that four out of five of the products did not contain any of the herbs on their labels. The tests showed that pills labeled medicinal herbs often contained little more than cheap fillers like powdered rice, asparagus and houseplants, and in some cases substances that could be dangerous to those with allergies.”

This could be attributed to what many in the natural products industry had already believed – that the products carried under the brand of big box retailers like Wal-Mart might be less than stellar quality.  The unfortunate reality might also be that this could have negative ramifications for other companies as well.

Today the American Herbal Products Association (AHPA) responded publicly to the charges from the NY State Attorney’s office by saying “the New York State Attorney General used an inadequate and unproven analytical method to test herbal supplement products at the core of the State’s allegations that several retailers are selling adulterated and/or mislabeled herbal dietary supplements. The results of this analysis, therefore, cannot be considered valid. According to AHPA Chief Science Officer Maged Sharaf, Ph.D., the New York State Attorney General and the laboratory that conducted the analysis relied on an analytical technology that does not have the capacity to reach the degree of certainty represented by the State in its accusations.”

While this is clearly an evolving case, it underscores the need for consumers to support high quality natural products supplements that use the kind of rigors in keeping with GMP.  Read more about AHPA’s response here.


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Why the National Cancer Institute research on CBD makes it hard on manufacturers of dietary supplements

Admittedly, this is a bit of a paradox which can be answered in six words. “Because we can’t talk about it.”

Here is their page on cannabinoids for health practitioners.

The Dietary Supplementation Health Education Act (DSHEA) prevents dietary supplement manufacturers from talking about research that indicates their products may treat, or even PREVENT, any kind of disease or health condition.  Cancer definitely falls under that category.

So lets say, hypothetically, that you are a manufacturer of dietary supplements who is releasing a new product that is made of the natural Cannabis sativa cannabinoid CBD (cannabidiol).  Wouldn’t you want to tell the world if there was information that indicated that your product could address cancer? We know from other countries where CBD (and even THC which is illegal in 48 of 50 states) is sold as a prescription drug for conditions such as epilepsy, pediatric seizure disorder, anxiety, severe nausea and lack of appetite, that it can be a versatile natural substance. Helping to prevent cancer might be something folks would want to know about? Well, you, if you were a manufacturer of dietary supplements you wouldn’t be able to say that, or else risk the legal ramifications of being cited by the government’s Food and Drug Administration.  Of course in most cases in order to BE a manufacturer, you’d have to believe in Corporate_personhood because most supplement manufacturers are corporations. As well it should be.

I am not a manufacturer of dietary supplements, although I work with many companies that are and have for a long time, none of which I personally consider people.  I am an American citizen with first ammendment rights guaranteed by the constitution. So I can tell you what that link I posted to above says, just in case you haven’t clicked on it yet.

“CBD, in particular, is thought to have significant analgesic and anti-inflammatory activity without the psychoactive effect (high) of delta-9-THC.”

Antitumor Effects

One study in mice and rats suggested that cannabinoids may have a protective effect against the development of certain types of tumors.[3] During this 2-year study, groups of mice and rats were given various doses of THC by gavage. A dose-related decrease in the incidence of hepatic adenoma tumors and hepatocellular carcinoma (HCC) was observed in the mice. Decreased incidences of benign tumors (polyps and adenomas) in other organs (mammary gland, uterus, pituitary, testis, and pancreas) were also noted in the rats. In another study, delta-9-THC, delta-8-THC, and cannabinol were found to inhibit the growth of Lewis lung adenocarcinoma cells in vitro and in vivo .[4] In addition, other tumors have been shown to be sensitive to cannabinoid-induced growth inhibition.[58]

Cannabinoids may cause antitumor effects by various mechanisms, including induction of cell death, inhibition of cell growth, and inhibition of tumor angiogenesis invasion and metastasis.[912] Two reviews summarize the molecular mechanisms of action of cannabinoids as antitumor agents.[13,14] Cannabinoids appear to kill tumor cells but do not affect their nontransformed counterparts and may even protect them from cell death. These compounds have been shown to induce apoptosis in glioma cells in culture and induce regression of glioma tumors in mice and rats. Cannabinoids protect normal glial cells of astroglial and oligodendroglial lineages from apoptosis mediated by the CB1 receptor.[15]

An in vitro study of the effect of CBD on programmed cell death in breast cancer cell lines found that CBD induced programmed cell death, independent of the CB1, CB2, or vanilloid receptors. CBD inhibited the survival of both estrogen receptor–positive and estrogen receptor–negative breast cancer cell lines, inducing apoptosis in a concentration-dependent manner while having little effect on nontumorigenic, mammary cells.[19]

CBD has also been demonstrated to exert a chemopreventive effect in a mouse model of colon cancer.[20] In the experimental system, azoxymethane increased premalignant and malignant lesions in the mouse colon. Animals treated with azoxymethane and CBD concurrently were protected from developing premalignant and malignant lesions. In in vitro experiments involving colorectal cancer cell lines, the investigators found that CBD protected DNA from oxidative damage, increased endocannabinoid levels, and reduced cell proliferation. In a subsequent study, the investigators found that the antiproliferative effect of CBD was counteracted by selective CB1 but not CB2 receptor antagonists, suggesting an involvement of CB1 receptors.[21]

Another investigation into the antitumor effects of CBD examined the role of intercellular adhesion molecule-1 (ICAM-1).[12] ICAM-1 expression has been reported to be negatively correlated with cancer metastasis. In lung cancer cell lines, CBD upregulated ICAM-1, leading to decreased cancer cell invasiveness.

In an in vivo model using severe combined immunodeficient mice, subcutaneous tumors were generated by inoculating the animals with cells from human non-small cell lung carcinoma cell lines.[22] Tumor growth was inhibited by 60% in THC-treated mice compared with vehicle-treated control mice. Tumor specimens revealed that THC had antiangiogenic and antiproliferative effects. However, research with immunocompetent murine tumor models has demonstrated immunosuppression and enhanced tumor growth in mice treated with THC.[23,24]

In addition, both plant-derived and endogenous cannabinoids have been studied for anti-inflammatory effects. A mouse study demonstrated that endogenous cannabinoid system signaling is likely to provide intrinsic protection against colonic inflammation.[25] As a result, a hypothesis that phytocannabinoids and endocannabinoids may be useful in the risk reduction and treatment of colorectal cancer has been developed.[2629]

CBD may also enhance uptake of cytotoxic drugs into malignant cells. Activation of the transient receptor potential vanilloid type 2 (TRPV2) has been shown to inhibit proliferation of human glioblastoma multiforme cells and overcome resistance to the chemotherapy agent carmustine.[30] In an in vitro model, CBD increased TRPV2 activation and increased uptake of cytotoxic drugs, leading to apoptosis of glioma cells without affecting normal human astrocytes. This suggests that coadministration of CBD with cytotoxic agents may increase drug uptake and potentiate cell death in human glioma cells.

The page also covers very well the research on appetitie stimulation and analgesia (pain relief).  Neither of which the makers of dietary supplements will let you know about it. “Because we can’t talk about it.”

God bless America.


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Can Humic and Fulvic Acid benefit the immune system?

Humic Acid and Fulvic Acid are unique organic compounds found in nature which have shown promise in scientific research regarding the reduction of heavy metals in the environment, in animals, and more recent research suggests that they may also benefit the human immune system.Virus ENVC

Researcher Dr Richard Laub has published new and interesting approaches to examining these benefits through his work with the National Institutes of Health http://livingorganicearth.wordpress.com/2013/12/03/dr-richard-laub-discusses-humic-and-fulvic-acid-for-human-health/

In a product like Alkalize 55, or Whole Earth Minerals, the unique humic compounds are found along with 70+ trace minerals which may hold the key to hidden mysteries within the cells of the human body as well.  You can see why some of us are greatly interested in combing humic fulvate minerals with foods, based on the cutting edge research currently going on.

Consider this study entitled “Genetic diversity-independent neutralization of pandemic viruses (e.g. HIV), potentially pandemic (e.g. H5N1 strain of influenza) and carcinogenic (e.g. HBV and HCV) viruses and possible agents of bioterrorism (variola) by enveloped virus neutralizing compounds (EVNCs).” and published in the journal Vaccine, which explores combining fulvic acid with pomegranate as an “enveloped virus neutralizing compound”

http://www.ncbi.nlm.nih.gov/pubmed/?term=fulvic+acid+pomegranate

DISCLAIMER : These statements have not been evaluated by the FDA and are not meant to imply that any product will prevent or treat disease.


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Dr Oz Defends Monsanto

dr-oz

If you work in the natural products industry, you may have mixed feelings about TV personality Dr Oz.  I personally am thankful for the attention he has brought to nutritional supplements, but I often find myself forced to take issue with his seemingly infinite wisdom. (One 400 mg capsule of Moringa? Would you eat 400 mg of Spinach? But, I digress…)

The latest from Dr Oz may truly shock you and make the late Rachel Carson roll over in her grave.  While seemingly all of the civilized world has come out against GMOs (and Monsanto in particular), Dr Oz has chosen to speak out in favor of genetically-modified organisms, saying they are the same as Organic.  See his comments here.

gmo protest chicago

Meanwhile the nation of Peru has recently passed a 10 year ban on GMOs. For further reference, here is a list of countries that have banned GMOs unlike the United States which has inexplicably sided with the interests of big business rather than the interests of the general health of the American people.

In fact, the lack of required GMO labeling in the US lends a lot of credibility to the Organic movement.  At least someone is required to demonstrate that their food has not been genetically-modified, if only the growers and processors of Organic food.

I will say this; while I respect the right of others to disagree or to believe that genetic modifications to food are not harmful, I hope that Dr Oz will be taken to task for his broad statements in favor of GMOs.  One of the largest arguments against GMOs is that there is VERY LITTLE research into what their actual effects on the human body are.

For 8 other reasons to avoid GMOs catch the foodie buzz at Organic Authority.


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FDA Agrees to Change NDI Draft Guidelines : Cheers Go Up from the Rooftops!

The Natural Products Industry collectively breathed a sigh of relief today as the Food and Drug Administration announced that it would revisit and revise the New Dietary Ingredients draft guidance it had put forth nearly a year ago.The NDI draft guidance the FDA had drafted in 2011 has been very controversial, in part because it was expected to render many commonly available dietary supplements illegal unless they complied with unrealistic requirements set forth by the government.

According to a statement issued by New Hope 360 “FDA has agreed to issue a new, revised New Dietary Ingredients draft guidance after a top-level meeting including Sens. Tom Harkin and Orrin Hatch and Commissioner Margaret Hamburg.”

“It is deeply gratifying to hear that FDA has decided to rethink its approach to good guidance on this important element of DSHEA,” said Michael McGuffin, president of the American Herbal Products Association. “We look forward to working more closely with the agency in the development of the kind of guidance that is needed by the supplement trade to ensure compliance with this important safety feature of the law.”

“It would be premature for industry to celebrate, but we should be buoyant,” said Steve Mister, president and CEO of the Council for Responsible Nutrition. “This is an indication that FDA has heard the industry and will work with the industry.”